INSIDE THE NANOQUICK S SYSTEM
A product intended to deliver into the bloodstream must specify how it is delivered, not just what Active Pharmaceutical Ingredient (“API”) it contains. If there is no delivery system, specifically when attempting to deliver oil-soluble APIs the user will absorb very little (0% to approx 10%) of the API compared to 40%-100% when using a validated API delivery system. Label and anecdotal user claims do not replace science and transparency.
All API delivery systems must independently show the structure and stability of their API delivery platform. The following describes the nanoQuick S benefits using independent 3rd-party lab testing using three metrics utilized by pharmaceutical companies worldwide: Particle Size, The Polydispersity Index (PDI) and the Zeta Potential.
In a finished canned beverage, functional shot, or sublingual tincture, a concentrate is diluted hundreds of times, and the pH drops. Acids, electrolytes, sweeteners, and citrus flavor oils enter the solution, placing suspended active ingredients under constant thermodynamic stress across weeks and months of warehousing, shipping, and cold storage. Once consumed, conventional oil emulsions face a second barrier: they must travel down the esophagus, survive stomach acid, and wait 45 to 90 minutes for bile salts and digestive enzymes to break them down before meaningful absorption can begin.
Standard "water-soluble" cannabinoid and nutraceutical emulsions try to solve this by shearing carrier oils into sub-micron droplets. At monarQh, we took a fundamentally different approach with nanoQuick S (Systemic / Sublingual Delivery).
nanoQuick S is not an oil-in-water emulsion. It is a patent-pending, oil-free, water-soluble micellar colloidal suspension engineered to encapsulate lipophilic active pharmaceutical ingredients (APIs) inside ultrasmall, thermodynamically stable micelles. No single laboratory number tells the full story of a delivery system. Particle size, distribution breadth, optical transmittance, and surface charge each examine a different physical force. Confidence comes when every instrument points in the same direction across repeated production runs.
1. Start with the Micelles
Measurement: Dynamic Light Scattering (DLS, ISO 22412) | nanoQuick S Average: 32.49 ± 0.51 nm
DLS sizes suspended nanoparticles by tracking the speed of their Brownian motion—how rapidly they diffuse through liquid. In colloid physics, reducing droplet radius exponentially slows gravitational creaming velocity while expanding active surface area by orders of magnitude.
While conventional beverage nanoemulsions typically measure 150 to 275 nm, triplicate DLS analysis on an Anton Paar Litesizer 500 (20.0 °C, 173° backscatter) confirms that nanoQuick S self-assembles at an average hydrodynamic diameter of 32.49 ± 0.51 nm across independent runs (32.29 nm, 33.06 nm, and 32.10 nm).
Operating in the sub-35 nm regime transforms both shelf performance and human pharmacokinetics:
-
Zero Creaming or "Ringing": At 32.5 nm, thermal Brownian kinetic energy completely overwhelms gravitational buoyancy, preventing oil separation or neck-ringing in cans and bottles.
-
Crystal-Clear Optical Transmittance: Because particles below 40 nm fall well below the wavelength of visible light, nanoQuick S achieves 71.08% optical transmittance in aqueous dispersion, preventing beverage cloudiness or turbidity.
-
Sublingual & Mucosal Permeation: Without a bulky oil core blocking diffusion, 32.5 nm micelles rapidly permeate sublingual, buccal, and upper-gastrointestinal mucosal membranes. By entering the bloodstream through the mouth and throat rather than waiting for intestinal digestion, nanoQuick S delivers onset in as little as 5 minutes, with 90%+ bloodstream absorption potential.
2. Then Look at the Population
Measurement: Polydispersity Index (PDI) | nanoQuick S Average: 0.164 ± 0.014 (16.43%)
Two formulations can share a similar average size while behaving completely differently on the shelf. An average diameter could come from a tight, uniform population—or from a volatile mix of tiny micelles and large oil globules that quickly separate. PDI quantifies the width of that population distribution; values near 0 represent identical spheres, and pharmaceutical standards require PDI ≤ 0.25.
Across triplicate runs, nanoQuick S achieved a PDI of 0.164 ± 0.014 (14.96%, 16.65%, and 17.66%), with 100.0% of scattered light intensity concentrated in a single monomodal peak centered at 35.19 ± 0.83 nm and zero secondary aggregate populations detected.
Instability over shelf life is driven by population breadth. In polydisperse mixtures, internal Laplace pressure differences force active ingredients out of small droplets and into larger ones—a process known as Ostwald ripening. By eliminating large outlier droplets at formation (D90 = 52.99 ± 2.01 nm) and maintaining a batch-to-batch diameter coefficient of variation (CV) of just 1.57%, nanoQuick S shuts down Ostwald ripening and guarantees uniform, homogenized dosing in every unit.
3. Resists Destabilization
Measurement: Zeta Potential by Electrophoretic Light Scattering (ELS, ISO 13099-2) | nanoQuick S Average: -16.79 ± 1.84 mV
Zeta potential measures the electrical charge at a particle's hydrodynamic slipping plane by tracking how fast particles migrate in an applied electric field. Traditional oil-in-water beverage emulsions rely almost exclusively on strong negative charges (-40 mV or higher) to keep droplets apart through electrostatic repulsion.
However, pure electrostatic repulsion has a well-documented vulnerability: once a concentrate is diluted into an acidic beverage (pH 2.5–4.0) containing electrolytes, salts, or mineral water, free ions compress the electrical double layer and dampen surface charge.
nanoQuick S is engineered with a dual-defense stabilization architecture:
-
Non-Ionic Steric Shielding: Its amphiphilic micellar shell forms a dense, hydrated polymer brush around the active core, creating an entropic physical barrier that prevents micelle collision and fusion regardless of pH drops, electrolytes, or competing flavor oils.
-
Moderate Electrostatic Repulsion: Confirmed by triplicate ELS testing at -16.79 ± 1.84 mV (electrophoretic mobility of -1.19 ± 0.13 μm·cm/V·s), this moderate negative charge provides secondary Coulombic separation while allowing micelles to pass unimpeded across negatively charged oral and gastric mucin layers without electrostatic entrapment.
4. Convergence Across Triplicate Analytical Testing
5. Stability & Finished-Matrix Performance
Baseline particle sizing proves that nanoQuick S forms an exceptionally tight, oil-free micellar suspension at manufacture. To validate commercial durability across beverages, sublingual sprays, water-phase gummies, and transdermal bases, monarQh pairs baseline DLS/ELS characterization with:
-
Finished-Matrix & Acid Stress Testing: Challenging nanoQuick S in low-pH, high-electrolyte, and terpene/flavor-oil beverage matrices to verify that steric hydration preserves sub-40 nm sizing and optical clarity without phase separation.
-
ICH Q1A Accelerated & Real-Time Stability: Tracking droplet diameter, PDI, and active potency under accelerated thermal stress (40 °C / 75% RH) alongside real-time ambient storage to confirm multi-month commercial shelf life and packaging compatibility across aluminum cans, glass, PET, and Tetra Pak.
